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Ivermectin as a Heartworm Preventive Medication in Dogs
Ivermectin is approved by the United States Food and Drug Administration (FDA) to prevent heartworm infections in dogs. Products containing ivermectin are normally administered monthly for heartworm prevention and include medications such as Heartgard®, Iverhart®, Tri-Heart® and many other generic ivermectin-based heartworm preventive medications.
When used as a heartworm preventive medicine, ivermectin is used at much lower dosages than when used for other purposes. When used at the lower heartworm prevention dosages, ivermectin has a much lower potential for side effects than when used at higher dosages and this is the reason that ivermectin is approved for use as a heartworm preventive medication but must be used off-label (in a fashion not approved by the FDA) for many other purposes.
Off-Label Usages of Ivermectin in Dogs
Ivermectin is used in higher dosages to treat both demodectic and sarcoptic mange in dogs. Ivermectin used in these dosages is considered to be an off-label use of ivermectin as the drug is not approved by the FDA when used at these dosages. Off-label usage is common and ivermectin is frequently used by veterinarians to treat mange in dogs but dog owners should be aware that the dosages are much different than those dosages used for monthly heartworm prevention.
Side Effects Associated with Ivermectin in Dogs
While ivermectin is considered to be a reasonably safe drug, even at dosages used for treatment of mange in dogs, side effects can occur. In addition, some dogs may harbor a genetic predisposition to ivermectin sensitivity which places them at further risk, especially when ivermectin is used at higher dosages.
Side effects most commonly seen with ivermectin are:
depression
lethargy
vomiting
diarrhea
lack of appetite
incoordination
seizures
excessive salivation
Ivermectin should not be used in high dosages with valium or tranquilizers related to valium, amitraz dips, collars or topical treatments, or Comfortis® due to the potential of adverse drug interactions.
Dogs with a Genetic Sensitivity to Ivermectin
Breeds which may possess a genetic sensitivity to ivermectin are Collies, Shetland Sheepdogs and Old English Sheepdogs, although genetic sensitivities have been seen in individuals outside of these breeds as well. A blood test which detects the genetic mutation responsible for the ivermectin sensitivity is available and may be advisable for high-risk dogs before administration of high dosages of ivermectin. Heartworm preventive dosages of ivermectin are normally low enough to be safe for these high-risk dogs.
Symptoms such as uncoordination and dilated pupils are of particular concern and can lead to death if treatment is not sought immediately.
http://petproducts.s...mectin_for_dogsStep
1Talk to your veterinarian before using. Some dogs, like collies and mixed collies, cannot tolerate Ivermectin, the drug in Ivomec. In addition, it is not safe to use on dogs less than six weeks old.
Step
2Give correct dosing. Be sure to talk this over with your vet first since dosing amounts vary among dogs, but general dosing guidelines are as follows:
0.0015 to 0.003 mg per pound for heartworm prevention; 0.15 mg per pound two times (14 days apart) for skin parasites; and 0.1 mg per pound one time for gastrointestinal parasites.
Step
3Administer Ivomec orally. It comes as an injection for cattle and swine, but
do not inject your dog. Rather, draw out the needed amount with the provided needle and then transfer to a needle-less syringe, like those used to administer oral medicines to children. Hold your dog's nose and squeeze the medication into his mouth.
Step
4Watch for side effects or overdosing. Look for stumbling, tremors, weakness, disorientation, blindness, or other odd behaviors. Consult a veterinarian immediately if you notice a possible side effect.
Tips & Warnings
Mix the Ivomec with some soft drink or orange juice so it will taste better for your dog.
http://www.ehow.com/...ormer-dogs.html
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